Human antibody targeting <i>Vibrio cholerae</i> O1 O-specific polysaccharide induces an amotile hypovirulent bacterial phenotype: mechanism of protection against cholera.

ABSTRACT: Antibodies targeting the O-specific polysaccharide (OSP) of Vibrio cholerae O1 are crucial determinants of protection against cholera. These antibodies agglutinate bacteria and, even in sub-agglutinating conditions, inhibit V. cholerae motility. To explore additional effects of OSP-specific antibodies, we examined the transcriptomic profiles of V. cholerae exposed to a human anti-OSP monoclonal antibody in the presence of mucin, the main component of intestinal mucus, and the substance in which V. cholerae and mucosal antibodies interact in infected humans. Beyond genes whose transcript levels were affected by either mucin alone or antibody alone, we identified a set of genes whose expression levels were specifically altered in the presence of both anti-OSP anti

SUBMITTER: Verma S 

PROVIDER: S-EPMC12505965 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature