Proteomic profile at the time of surgery correlates with disease stage and surgical outcome in periprosthetic joint infection.

ABSTRACT: Periprosthetic joint infection (PJI) is the most common and difficult to treat form of arthroplasty failure. While treatment with debridement, antibiotics, and implant retention (DAIR) is preferable to one- or two-stage implant exchange based on morbidity and cost, outcomes are not successful in all cases selected for this management strategy. DAIR is currently recommended when infection is perceived to be in an "acute" phase, based on symptom duration; despite this selection strategy, DAIR failure rates are high. A more objective means of predicting DAIR success could improve patient outcomes by limiting DAIR failures. To explore this possibility, advanced proteomic analysis of sonicate fluid samples from 95 subjects with PJI was performed using proximity extension assay (PEA), with 77 sa

SUBMITTER: O'Connor K 

PROVIDER: S-EPMC12505968 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature