Acetic acid produced by <i>Staphylococcus epidermidis</i> remodels chromatin architecture and suppresses gene expression in <i>Malassezia restricta</i>.

ABSTRACT: The skin microbiome is composed of diverse microbial communities that engage in interkingdom interactions, influencing host physiology and microbial balance. Although Malassezia restricta and Staphylococcus epidermidis are codominant members of the human skin microbiome, the molecular mechanisms underlying their interactions remain poorly understood. We aimed to investigate the mechanism by which S. epidermidis-derived acetic acid affects chromatin organization and gene expression in M. restricta. S. epidermidis modulated chromatin structure and transcriptional activity in M. restricta by secreting acetic acid (AcOH), a common skin-associated organic acid. Using in situ Hi-C, we established the first three-dimensional genome architecture map of

SUBMITTER: Lee JM 

PROVIDER: S-EPMC12505993 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature