TNF signaling maintains local restriction of bacterial founder populations in intestinal and systemic sites during oral <i>Yersinia</i> infection.

ABSTRACT: Enteroinvasive bacterial pathogens are responsible for an enormous worldwide disease burden that critically affects the young and immunocompromised. Yersinia pseudotuberculosis is a gram-negative enteric pathogen closely related to the plague agent Y. pestis that colonizes intestinal tissues, induces the formation of pyogranulomas along the intestinal tract, and disseminates to systemic organs following oral infection of experimental rodents. Prior studies proposed that systemic tissues were colonized by a pool of intestinal replicating bacteria distinct from populations within Peyer's patches and mesenteric lymph nodes. Whether bacteria within intestinal pyogranulomas serve as the source for systemic dissemination and the relationship between bacterial populations within dif

SUBMITTER: Peterson ST 

PROVIDER: S-EPMC12506003 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature