Sickle cell allele distribution in southern India: a population-based study in a rural-tribal context.

ABSTRACT:

Background and objective

Sickle cell disease (SCD) is a genetic disorder of haemoglobin affecting red blood cells with the second highest burden in India. In this study, we examine the epidemiology of SCD in Chamarajanagar district, a largely rural south Indian district in Karnataka with a mixed rural tribal and non-tribal population to generate a more comprehensive understanding of the prevalence of SCD in southern India through the axes of social demographics.

Methods

We collected household and individual sociodemographic data and blood samples for determining SCD status using a cross-sectional study design among a subsample of consenting participants from forest-dwelling tribal communities and non-tribal communities. This study is nested in a previous study, 'Towards Heal

SUBMITTER: Channa Basappa Y 

PROVIDER: S-EPMC12506035 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature