Comparative efficacy and safety of high-dose rifamycin regimens for tuberculosis treatment: a Bayesian network meta-analysis.

ABSTRACT:

Objectives

High-dose rifamycin (HDR) regimens have demonstrated significant potential in tuberculosis (TB) treatment. This study aims to evaluate the efficacy and safety profile of different HDR regimens.

Design

Using a systematic review and Bayesian network meta-analysis (NMA).

Data sources

PubMed, Web of Science, Cochrane Library and Embase were searched up to 2 November 2024.

Eligibility criteria for selecting studies

Randomised controlled trials that compared the efficacy and safety of HDR regimens (rifampin 15-30 mg/kg/day and rifapentine 7.5-20 mg/kg/day) to standard-dose rifampin in patients with pulmonary drug-susceptible TB were included.

Data extraction and synthesis

The risk of bias was assessed using Cochrane tools. We conducted NMA with GEMT

SUBMITTER: Feng Z 

PROVIDER: S-EPMC12506051 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature