PRRSV promotes bacterial infection by remodeling actin cytoskeleton and cell membrane proteins.

ABSTRACT: Secondary infection is a worldwide problem in the prevention and control of viral infection. Secondary bacterial infection induced by porcine reproductive and respiratory syndrome virus (PRRSV) infection causes enormous economic losses, but the relevant mechanism remains unclear. We found that the infection of Klebsiella pneumoniae or Streptococcus suis type 2 in the lungs of PRRSV-challenged piglets was significantly higher than the controls, and the infection of PRRSV, influenza A virus H1N1 (H1N1), and porcine circovirus type 2 (PCV2) also significantly increased the infection of the bacteria in vitro. Transcriptomic analysis revealed that PRRSV infection significantly altered the expression of cytoskeleton-related proteins, among which the expression of actin-bindi

SUBMITTER: Liu X 

PROVIDER: S-EPMC12506063 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature