Combinatorial effects of tryptophan derivatives serotonin and indole on virulence modulation of enteric pathogens.

ABSTRACT: There is a wealth of signals present in the human gut that mediate host-microbiota communication and intersect with the gut-brain-axis. There is differential spatial localization of the tryptophan derivatives serotonin and indole in the gut, which are important cues for enteric pathogens to find their colonization niche. Both signals are sensed by enteric pathogens such as enterohemorrhagic Escherichia coli (EHEC) and Citrobacter rodentium, a murine pathogen extensively employed as a surrogate animal model for EHEC. EHEC and C. rodentium virulence determinants include genes necessary for the attaching and effacing (AE) lesion formation on enterocytes, which are contained within the locus of enterocyte effacement (LEE) pathogenicity island. Both signals inhibit LEE expr

SUBMITTER: Hoskan MA 

PROVIDER: S-EPMC12506081 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature