Perinatal and postpartum insulin secretion capacity in women with early-onset and late-onset gestational diabetes.

ABSTRACT:

Introduction

Gestational diabetes mellitus (GDM) is associated with metabolic risks and adverse maternal and fetal perinatal outcomes. This study aimed to compare pregnancy outcomes, postpartum glucose intolerance and insulin secretion capacity in women with early-onset GDM (EGDM, diagnosed<24 weeks) and late GDM (LGDM, diagnosed≥24 weeks) in Japan.

Research design and methods

This single-center, retrospective study included 107 women with EGDM and 109 with LGDM. GDM was diagnosed through the 75 g oral glucose tolerance test. Postpartum glucose tolerance was assessed 4-16 weeks post partum. Maternal and neonatal outcomes, insulin secretion, and postpartum glucose tolerance were analyzed and compared. Subgroup analyses were performed for women with and without obesity.

Res

SUBMITTER: Katayama A 

PROVIDER: S-EPMC12506086 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature