Different responses of luminal and glandular epithelium during mouse embryo implantation.

ABSTRACT:

Introduction

Embryo implantation, a crucial process for establishing and maintaining a successful pregnancy, involves the attachment and invasion of the embryo into the endometrium. The glandular epithelium (GE) within endometrial glands secretes multiple factors to support embryonic development, while the luminal epithelium (LE) covering the endometrial surface directly interacts with the embryo and regulates its invasion. This study uses RNA sequencing to examine the different responses of luminal epithelium (LE) and glandular epithelium (GE) during mouse embryo implantation.

Methods

We performed the RNA-seq using the mouse model of delayed and activated implantation to investigate the distinct regulatory mechanisms of LE and GE at 0 h, 3 h, and 6 h after initiating embryo

SUBMITTER: Cui W 

PROVIDER: S-EPMC12506090 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature