The MarR family transcription factor SlyA senses iron and respiratory status in enteric bacteria.

ABSTRACT: SlyA and its homologs are conserved transcription factors in enteric bacteria, including Salmonella enterica, in which it upregulates horizontally acquired virulence genes. SlyA is a member of the MarR family of transcription factors, which possess a small molecule binding pocket. Ligand binding causes the protein to undergo a conformational change that abrogates DNA binding. Although the original discovery of MarR was based on its ability to recognize xenobiotic compounds and promote their efflux, the conservation of MarR family members throughout Bacteria and Archaea suggests a more general function. Because SlyA is known to bind xenobiotic aromatic carboxylates, we performed a targeted analysis of aromatic metabolic genes in Salmonella Typhimurium to identify potential end

SUBMITTER: Will WR 

PROVIDER: S-EPMC12506092 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature