A novel regulator of the fungal phosphate starvation response revealed by transcriptional profiling and DNA affinity purification sequencing.

ABSTRACT: Cells must accurately sense and respond to nutrients to compete for resources and establish growth. Phosphate is a critical nutrient source necessary for signaling, energy metabolism, and synthesis of nucleic acids, phospholipids, and cellular metabolites. During phosphate limitation, fungi import phosphate from the environment and liberate phosphate from phosphate-containing molecules in the cell. In the model filamentous fungus Neurospora crassa, the phosphate starvation response is regulated by the conserved transcription factor NUC-1. The activity of NUC-1 is repressed by a complex of the cyclin-dependent kinase MDK-1 and the cyclin PREG when phosphate is plentiful. When phosphate is limiting, NUC-1 repression by MDK-1/PREG is relieved by the cyclin-dependent kinase inhibitor NU

SUBMITTER: Huberman LB 

PROVIDER: S-EPMC12506109 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature