The protective effect of breastfeeding on infant inflammation: a mediation analysis of the plasma lipidome and metabolome.

ABSTRACT:

Background

Inflammation has long-term health impacts across the life course. Breastfeeding substantially reduces inflammation risk, but key pathways, including the extent that this is due to protection against early life infection, are poorly understood. We aimed to investigate the relationships between breastfeeding, inflammation, and infection burden, and to determine the extent to which metabolomic and lipidomic profiles associated with breastfeeding mediate these health outcomes.

Methods

We utilised data from the Barwon Infant Study (BIS), a longitudinal birth cohort in Victoria, Australia. Infants (n = 889) with available breastfeeding (categorised as yes/no) clinical, metabolomic, and Lipidomic data at 6 and/or 12 months were included (n = 793 at 6 months, n = 734 at 1

SUBMITTER: Burugupalli S 

PROVIDER: S-EPMC12506166 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature