MaxiMoM InForM: individualised fortification of human milk for very low birthweight infants- protocol of a three-arm randomised clinical trial.

ABSTRACT:

Introduction

To meet the elevated nutritional requirements of very low birthweight (<1500 g, VLBW) infants during hospitalisation, many neonatal units routinely add a fixed dose of multinutrient fortifier to human milk. Individualised approaches that either tailor macronutrient additions to routine analysis of milk composition (target fortification) or an infant's metabolic response to nutrition (blood urea nitrogen (BUN) adjustable fortification) show short-term improvement in growth, but important outcomes such as longer-term neurodevelopment and major in-hospital morbidity have not been systematically assessed. The aim of our study is to determine whether target or BUN adjustable fortification of human milk, compared with standard fortification, during hospitalisation improves c

SUBMITTER: Beggs MR 

PROVIDER: S-EPMC12506200 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature