Treatment outcomes in functional neurological disorder: a systematic review and meta-analysis exploring the influence of symptom chronicity.

ABSTRACT:

Background

Functional neurological disorder (FND) is a common cause of neurological disability with symptoms spanning motor, sensory and cognitive domains. While effective treatments exist, the impact of symptom chronicity on treatment outcomes is unclear. This systematic review and meta-analysis investigated whether longer symptom duration influences treatment outcomes across FND phenotypes: functional movement disorders, functional/dissociative seizures (FDS) and mixed presentations.

Methods

MEDLINE, Embase, Cochrane Central Register of Controlled Trials, PsycINFO and grey literature were systematically searched till 29 June 2024. Studies were included if they involved adult FND participants undergoing any intervention and evaluated symptom change, function and health-rela

SUBMITTER: Thomas ST 

PROVIDER: S-EPMC12506205 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature