Generation of equine induced pluripotent stem cells from cells of embryonic, perinatal and adult tissues.

ABSTRACT:

Background

Regenerative therapies are quickly expanding to application in equine patients because of their importance as sporting and companion animals. Furthermore, aligning with a One Health concept, veterinary medicine offers a unique platform for preclinical studies. While mesenchymal stem/stromal cells (MSCs) therapies are already used in treating horses, strategies involving induced pluripotent stem cells (iPSCs) are poorly developed. iPSCs present great potential for therapy and disease modelling, but their consistent generation in horses requires further investigation into the source of somatic cells and the reprogramming method and conditions.

Methods

The reprogramming potential of equine cells from tissues of three developmental origins was compared: prenatal (embr

SUBMITTER: Barrachina L 

PROVIDER: S-EPMC12506261 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature