SENP1 drives glycolysis and cisplatin resistance in gastric cancer via desumoylating ENO1.

ABSTRACT:

Background

Gastric cancer remains a leading cause of cancer-related mortality in world, with advanced-stage patients facing poor prognosis despite emerging therapies. SUMOylation modification is a major post-translation modification, which is essential for cellular behaviors. However, the potential function of SUMOylation in gastric cancer (GC) and the underlying molecular mechanisms remain unclear.

Methods

In our study, a bioinformatics analysis was conducted to screen potential regulators within the SUMO-Specific Peptidase (SENP) family in GC. In vitro functional experiments including CCK8, colony formation, transwell assay, sphere formation, Glycolytic flux, ECAR and OCR and several animal models including GC xenografts, organoids and lung metastasis models were employed

SUBMITTER: Fang Y 

PROVIDER: S-EPMC12506269 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature