Differential contributions of cardiovascular health-related lifestyle factors to epigenetic ageing: implications for healthy longevity.

ABSTRACT:

Background

Lifestyle and cardiovascular health (CVH) are key determinants of the biological ageing process, which is closely linked to healthy ageing and longevity. Multiple CVH factors may interact and exert combined effects on the biological ageing process; however, studies exploring their collective association, particularly in Asian cohorts, remain limited. In this cross-sectional study, we investigated the relative contributions of CVH-related behaviours (diet, sleep, avoidance of nicotine, and physical activity) and clinical indicators (BMI, blood lipids, blood glucose, and blood pressure) to epigenetic age acceleration (EAA), as well as their collective associations.

Methods

We included 1940 participants from two large-scale prospective cohorts within the Korean Genom

SUBMITTER: Lee DE 

PROVIDER: S-EPMC12506275 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature