Association of longitudinal blood urea nitrogen trajectory with in-hospital and 28-day mortality in acute heart failure with cardiorenal syndrome.

ABSTRACT:

Background and objective

Patients with acute heart failure (AHF) complicated by acute cardiorenal syndrome (CRS) demonstrate substantial mortality risk. Conventional blood urea nitrogen (BUN) assessments using single-point measurements inadequately capture the temporal dynamics of renal dysfunction and disease progression. This study investigated the prognostic utility of BUN trajectory patterns for predicting in-hospital and 28-day mortality in AHF patients with CRS.

Methods

We conducted a retrospective cohort study using the Medical Information Mart for Intensive Care IV (MIMIC-IV) database as the derivation cohort and the eICU Collaborative Research Database (eICU-CRD) as the validation cohort. BUN measurements were obtained at baseline (< 24 h), 72 h, and 144 h across bo

SUBMITTER: Liu P 

PROVIDER: S-EPMC12506301 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature