Analysis of ultrastructural defects in sperm by transmission electron microscopy in asthenozoospermia patients: a study from multiple centers across China.

ABSTRACT: This study aimed to identify the ultrastructural features of sperm in Chinese asthenozoospermia patients and to evaluate their clinical implications. A total of 139 individuals, including 106 asthenozoospermia patients and 33 fertile controls, were recruited from multiple centers across China. Sperm ultrastructural defects were examined using transmission electron microscopy (TEM), while conventional sperm quality was assessed by light microscopy. Compared with the control group, the asthenozoospermia group showed significant ultrastructural defects, particularly in the sperm tail, including mitochondrial and axonemal defects. Based on tail ultrastructure, participants were further categorized into four groups (normal ultrastructure, simple abnormal axonemes, simple abnormal mitochondria,

SUBMITTER: Lv MQ 

PROVIDER: S-EPMC12506306 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature