Transcriptome analysis of five-toed jerboa organs reveals high-altitude adaptation mechanisms.

ABSTRACT: High-altitude environments are characterised by extreme conditions, including hypoxia, low temperatures, and intense ultraviolet radiation. Mammals inhabiting these environments have evolved unique adaptive mechanisms, the study of which elucidates survival strategies and evolutionary pathways under extreme conditions. Understanding how native high-altitude animals respond to such environments is highly important. This study investigated the high-altitude adaptation mechanisms of the five-toed jerboa (Orientallactaga sibirica) distributed in Qinghai Province (4229 m) and Hebei Province (498 m), China, through comparative transcriptomic analysis of heart, lung, and kidney tissues. The results revealed greater mRNA transcriptional differences in the lung tissue than in the heart and kidney t

SUBMITTER: Sun SS 

PROVIDER: S-EPMC12506385 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature