Multi-clade co-evolution and differential replication efficiencies of subgroup A avian leukosis virus in Chinese guinea fowl.

ABSTRACT: Avian leukosis virus (ALV) has a wide range of hosts and is Susceptible to commercial chickens, local chickens and rare birds. To assess the presence of ALV-A infection in guinea fowl and characterize its viral genetics, PCR testing of guinea fowl embryosfrom four provinces revealed an ALV-A positive rate of 68.1% (32/47) in China. Furthermore, phylogenetic analysis of the 15 ALV-A gp85 sequences obtained from guinea fowl-fertilized chicken embryos revealed four evolutionary clades (1, 2, 3, 4). Notably, no clade 1 isolates were detected in this study. Comparative sequence analysis demonstrated that amino acid variations among different clades primarily localized to host range determinant regions 1 and 2 (hr1 and hr2) of the gp85 protein. To systematically investigate the replicative poten

SUBMITTER: Chen J 

PROVIDER: S-EPMC12506397 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature