MyClone: rapid and precise reconstruction of clonal population structures for tumors.

ABSTRACT:

Background

Understanding tumor heterogeneity is essential for advancing cancer treatment. Clonal reconstruction methods play a pivotal role in deciphering this heterogeneity. Our goal is to develop a clonal reconstruction approach that is clinically applicable, easy to implement, and capable of delivering both high-speed performance and excellent reconstruction accuracy.

Results

We present MyClone, a probabilistic method designed to reconstruct the clonal composition of tumors using deep sequencing genomic data. MyClone processes read counts and copy number information of single nucleotide variants derived from deep sequencing data, enabling it to determine the mutational composition of clones and the cancer cell fractions of these mutations. Compared to existing clonal reco

SUBMITTER: Guo Q 

PROVIDER: S-EPMC12506407 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature