Thermosensitive antibacterial nanocomposite hydrogel guiding macrophage polarization and bone regeneration for periodontitis treatment.

ABSTRACT: Periodontitis is a chronic inflammatory disease caused by bacterial infection that leads to the destruction of periodontal tissues. Traditional treatment involves scaling and root planing combined with antibiotics, but systemic antibiotic therapy often results in insufficient drug concentration at the treatment site and unwanted side effects. Here, we developed a nanocomposite thermosensitive hydrogel (CFMD) designed for localized drug delivery. The chitosan-grafted Pluronic® F127 hydrogel (CP) had natural antibacterial activity. After the thermosensitive material flows into the periodontal pocket, it transforms into a gel phase at body temperature, filling the periodontal pocket and preserving the nanomedicine. As the hydrogel retained in the periodontal pocket is degraded, folic acid-mod

SUBMITTER: Yu X 

PROVIDER: S-EPMC12506435 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature