Prediction model for renal outcomes in Latin American Mestizo patients with pure proliferative lupus nephritis.

ABSTRACT:

Objective

Lupus nephritis (LN) is associated with a poorer prognosis in Latin American populations. However, the contributing risk factors contributing to this remain to be fully elucidated. This study aimed to develop a prognostic model for poor renal outcomes in patients of mestizo descent.

Methods

We conducted a multicentre, retrospective analysis including 290 adult mestizo patients with incident, biopsy-proven pure proliferative LN (International Society of Nephrology/Renal Pathology Society (ISN/RPS) class III or IV) from nine Chilean hospitals. Clinical, biological and histological variables were assessed. The primary outcome was a composite of stage IV/V chronic kidney disease, dialysis or death. Predictive variables were selected using multivariable Cox regression,

SUBMITTER: Villalobos Navarro A 

PROVIDER: S-EPMC12506453 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature