Innate and adaptive immune features associated with immune-related adverse events.

ABSTRACT:

Background

While highly efficacious for numerous cancers, immune checkpoint inhibitors (ICIs) can cause unpredictable and potentially severe immune-related adverse events (irAEs), underscoring the need to understand irAE biology.

Methods

We used a multidimensional approach incorporating single-cell RNA sequencing, mass cytometry, multiplex cytokine assay, and antinuclear antibody (ANA) profiling to characterize the peripheral immune landscape of patients receiving ICI therapy according to irAE development.

Results

Analysis of 162 patients revealed that individuals who developed clinically significant irAEs exhibited a baseline proinflammatory, autoimmune-like state characterized by a significantly higher abundance of CD57⁺ T and natural killer (NK) T cells,

SUBMITTER: Khan S 

PROVIDER: S-EPMC12506470 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature