MELD 3.i: A Bayesian framework for updating the model for end-stage liver disease score.

ABSTRACT:

Background & aims

The model for end-stage liver disease (MELD) score has been central to liver transplant (LT) allocation since 2002, with iterative updates culminating in MELD 3.0. However, given temporal changes and variations in liver disease epidemiology across allocation systems that utilize MELD, continuous refinements are essential to ensure its optimal performance across diverse patient populations and transplant frameworks.

Methods

This retrospective cohort study included all US adult LT candidates listed between July 13, 2023 to June 30, 2024. Candidates from the first two-thirds of listing dates formed the training set, while the last third comprised the validation set. We applied a Bayesian proportional hazards model, using MELD 3.0 as informative priors to gener

SUBMITTER: Tanaka T 

PROVIDER: S-EPMC12506478 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature