Transcriptomic Architecture of Weak Versus Strong Contextual Fear Extinction Learning Uncovers Extinction-Suppressive Role of TIA1.

ABSTRACT:

Background

Extinction, the capacity for an individual to inhibit or diminish fear memories, is a critical aspect of fear processing. In humans, weak extinction learning is often observed in anxiety and fear-related disorders such as posttraumatic stress disorder. However, the mechanisms behind regulating extinction and determining individual variability in extinction learning remain poorly understood.

Methods

To investigate the molecular basis of interindividual and sex-related differences in the ability to extinguish fear, extinction learning was analyzed in inbred wild-type male and female mice. Contextual fear conditioning and extinction were combined with profiling of the hippocampal transcriptomes associated with weak and strong extinction learning and genetic manipulat

SUBMITTER: Bonilla MI 

PROVIDER: S-EPMC12506486 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature