Impact of remnant cholesterol on arterial stiffness and mediating role of systolic blood pressure in chinese hypertensive adults.

ABSTRACT:

Background

This study aimed to investigate the association between remnant cholesterol (RC) levels and arterial stiffness in hypertensive patients and to explore potential effect modifiers.

Methods

A cohort of 18,152 individuals diagnosed with hypertension was analyzed. RC was calculated using the Martin-Hopkins method, i.e., RC = total cholesterol (TC)-high-density lipoprotein cholesterol (HDL-C)-low-density lipoprotein cholesterol (LDL-C). Multivariate logistic regression models were employed to mitigate the influence of potential confounding factors and assess the association between RC and arterial stiffness (baPWV ≥ 1800 cm/s). Mediating analysis was conducted to determine the extent to which systolic blood pressure (SBP) mediates the correlation between RC and arterial

SUBMITTER: Yu C 

PROVIDER: S-EPMC12506517 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature