Identification of H1N2 influenza viruses in turkeys after spillover from swine and in vitro characterization.

ABSTRACT: Influenza A viruses (IAVs) circulate among animals and humans and can cross species barriers to adapt to new hosts. In France, since 2020, a new genotype named H1_avN2#E has predominated in pig farms. In parallel, this virus was detected in 19 breeding turkey flocks and in a human case, indicating interspecies transmission. The objectives of this study were (i) to analyze viral sequences detected in turkeys between April 2020 and January 2023 and compare them with swine sequences to identify potential markers of adaptation and (ii) to characterize three representative viruses in vitro and in ovo on MDCK, MLE15 and A549 cells, as well as on embryonated chicken eggs. Results suggest that following initial swine-to-turkey spillovers, the virus circulated between turkey farms. Phylog

SUBMITTER: Chavoix C 

PROVIDER: S-EPMC12506539 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature