Beyond the count: platelet dysfunction profile in pediatric trauma patients.

ABSTRACT:

Background

Existing clinical coagulation assays are inadequate to evaluate posttraumatic platelet dysfunction in children.

Objectives

To elucidate changes in flow-dependent platelet function after injury in children using a microfluidic assay.

Methods

We enrolled 18 children who presented with highest-acuity trauma activation and 10 healthy children at an academic pediatric center. For the control cohort, outpatient blood samples were collected, and for the trauma cohort, blood was collected in the trauma bay for conventional coagulation tests, thromboelastography, von Willebrand factor A1 domain activity, and a microfluidic assay using a stenotic channel (shear rate = 3500 s^-1).

Results

The trauma cohort characteristics were 67% male, median (IQR) a

SUBMITTER: Kar R 

PROVIDER: S-EPMC12506559 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature