Sonodynamic and Bioorthogonal Sonocatalytic Thrombotic Therapy Based on AIE Cationic Tetranuclear Ir(III) Complex Nanoplatform Guided by NIR-Chemiluminescence Imaging.

ABSTRACT: Non-invasive thrombolytic strategies include photothermal therapy (PTT), photodynamic therapy (PDT) and sonodynamic therapy (SDT). The development of PTT and PDT is impeded by the limited tissue penetration depth of the light source. SDT is a promising method due to the deeper tissue penetration and site-specific features of ultrasound; however, the scarcity of efficient sonosensitizers has constrained its clinical use. Herein, ultrasound-triggered nanoparticles (NPs), named Ir-4@S-R NPs, achieve a sonodynamic thrombolytic, bioorthogonal sonocatalytic reaction, with chemiluminescence (CL) imaging in the thrombus. An Ir(III) complex, named Ir-4, which has aggregation induced emission (AIE), combined with a hydrogen sulfide donor, named H₂S-N₃, provide the nanoplatform

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12506604 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature