Racial differences in kidney cancer histology and outcome: A nationwide study from the UroCCR Cohort.

ABSTRACT:

Introduction

Racial differences in renal cell carcinoma (RCC) have been well described in U.S. cohorts, particularly for common histologic subtypes. However, such differences remain underexplored in European populations, especially for rare RCC subtypes and within universal health care settings. We aimed to characterize racial differences in RCC histology, renal comorbidities, and clinical outcomes in France, and to investigate potential molecular underpinnings.

Methods

A total of 9404 patients were analyzed from the UroCCR national registry (1987-2024), including 338 Black and 9066 non-Black individuals with nephrectomy-confirmed diagnoses. Clinical features, histologic subtypes, and outcomes were compared between groups. Transcriptomic differences between Black and White i

SUBMITTER: Lu X 

PROVIDER: S-EPMC12506607 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature