Evaluating the Potential of Galactosaminogalactan as a Diagnostic Target for Invasive Aspergillosis.

ABSTRACT:

Background

Early diagnosis of invasive aspergillosis (IA) is critical for the initiation of effective antifungal therapy. Currently, detection of galactomannan (GM), a secreted fungal glycan, is the most used culture-independent diagnostic test for IA. However, limitations in the sensitivity and specificity of this test have led to interest in identifying other target molecules. Galactosaminogalactan (GAG), a polysaccharide cell wall component secreted by Aspergillus hyphae, is a potential diagnostic marker for IA.

Objectives

To evaluate the utility of GAG as a diagnostic target, we generated a monoclonal antibody against GAG (mAb 1D1), established a GAG enzyme-linked immunosorbent assay (ELISA), evaluated its cross-reactivity with other respiratory pathogens, and compared t

SUBMITTER: Takazono T 

PROVIDER: S-EPMC12506618 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature