A novel mutant allele of Mta3 in the mouse: genetic analysis of roles in immunity and androgen biology.

ABSTRACT: The metastasis associated (MTA) proteins, encoded in mammals by 3 highly similar gene paralogs, Mta1, Mta2, and Mta3, are integral components of the nucleosome remodeling deacetylase (NuRD) complex. While biochemical and molecular studies have probed the functions of the Mta gene family, genetic data in animals is less complete. Here we report the creation of a novel allele of Mta3 in which the first 2 coding exons, which encode the bromo-adjacent homology (BAH) domain of Mta3, are deleted. Animals homozygous for this Mta3ΔBAH allele are viable, fertile, and have no obvious deleterious phenotype. Exploration of the Mta3ΔBAH allele revealed that the Mta3 locus has an unannotated promoter located between Mta3 exons 3 and 4, which is unperturbed in the Mta3ΔBAH allele, which appears to drive

SUBMITTER: Chrysovergis K 

PROVIDER: S-EPMC12506663 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature