Untargeted metabolomic profiling in acute ischemic stroke patients with cerebral microbleeds.

ABSTRACT:

Background

Acute ischemic stroke (AIS) is a common cerebrovascular condition. Cerebral microbleeds (CMBs) are frequently observed in AIS patients and are closely associated with poor prognosis and potential therapeutic implications. Understanding the distinct metabolic profiles in AIS patients with CMBs is critical for uncovering the underlying pathophysiological mechanisms and identifying novel biomarkers.

Methods

An untargeted metabolomics approach using liquid chromatography-mass spectrometry (LC-MS) was employed to compare the metabolic profiles of 30 AIS patients with CMBs (CMB group) and 30 AIS patients without CMBs (the Non CMB group, abbreviated as NCMB group). Raw MS data were processed using MS-DIAL and metabolites were identified by comparison with public and in-h

SUBMITTER: Zhou L 

PROVIDER: S-EPMC12506673 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature