Synthesis, biological evaluation, and docking analysis of novel benzimidazole-triazole hybrids as potential anticancer agents.

ABSTRACT: A series of novel benzimidazole-triazole acetamide hybrids with different substitutions at the acetamide moiety were designed and synthesized in an effort to discover potential anticancer agents. The compounds were evaluated for their in vitro antiproliferative and cytotoxicity activities against two cancer cell lines (A549 and SW480) and a normal cell (MRC-5) using the MTT assay. The results revealed that most derivatives exhibited moderate to high levels of antiproliferative activity. Notably, derivative 9f emerged as the most potent antiproliferative agent with IC₅₀ values of 16.1 ± 1.1 and 19.7 ± 2.7 μM against A549 and SW480, respectively. Compound 9f showed significant selectivity towards A549 (SI = 7.5) and SW480 (SI = 6.1) cancer cells compared to the normal MRC-5

SUBMITTER: Shokouhi Asl AS 

PROVIDER: S-EPMC12506886 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature