<i>Mycoplasma synoviae</i> induce spleen tissue damage and inflammatory response of chicken through oxidative stress and apoptosis.

ABSTRACT: Mycoplasma synovium (MS) is a prominent avian pathogen known to elicit robust inflammatory responses in birds while evading immune detection, often leading to chronic infection and immune compromise. The mechanisms underpinning MS-mediated splenic tissue damage in chickens, however, remain undefined. In our investigation with 7-day-old SPF chickens, we administered an MS-Y bacterial solution (200 µl, 1 × 10⁹ CCU/ml) through eye and nose droplets, collecting spleen samples on days 3, 6, and 12 post-infection. Comprehensive analyses utilizing histopathology, electron microscopy, TUNEL assay, qRT-PCR, and western blot were employed. Results demonstrated that MS-infection downregulated T-SOD, GSH-PX, and CAT, while concurrently elevating iNOS, NO, and MDA levels. Evidently, M

SUBMITTER: Zhong L 

PROVIDER: S-EPMC12506914 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature