Aging and Host Responses to Severe Infection: Proteomic Analysis of a Prospective Multicenter Cohort From Uganda.

ABSTRACT:

Objective

Severe infectious diseases are a leading cause of morbidity and mortality worldwide, particularly in sub-Saharan Africa (SSA), where young and middle-aged adults are disproportionately affected. Although age-related immune changes such as inflammaging and immunosenescence have been well characterized in high-income countries, their relevance to host responses during infection in SSA remains poorly understood. We aimed to characterize age-associated differences in immune, metabolic, and endothelial responses to severe infection in a prospective, multicenter cohort of adults in Uganda.

Design

Prospective cohort study.

Setting

Two public referral hospitals in Uganda.

Patients

Non-pregnant adults (18 yr old or older) hospitalized with severe, undifferenti

SUBMITTER: Conte Cortez Martins G 

PROVIDER: S-EPMC12506988 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature