Association Between Donor-recipient Matchability, Access to Transplantation, and Posttransplant Outcomes.

ABSTRACT:

Background

Globally, deceased donor kidney allocation algorithms prioritize HLA matching, potentially disadvantaging transplant candidates with less common HLA alleles. This study developed an Australian Matchability score (M-score) to assess access to transplantation and posttransplant outcomes based on HLA match probability.

Methods

M-scores were calculated by comparing all recipients and donors with complete HLA-A, HLA-B, and HLA-DR data from the Australia and New Zealand Dialysis and Transplant Registry (July 1, 2006-December 31, 2023). Multivariable Cox regression was used to analyze associations between M-score quartiles and time to transplantation as well as transplantation outcomes.

Results

HLA data from 14 836 recipients and 7708 donors were used to generate

SUBMITTER: Lalji R 

PROVIDER: S-EPMC12506989 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature