The brown fat-enriched exosomal miR-206-3p attenuates hepatic lipogenesis by decreasing pentose phosphate pathway.

ABSTRACT: Brown adipose tissue (BAT) orchestrates interorgan crosstalk through secreted mediators, including proteins, lipids, and exosomal microRNAs (miRNAs). However, the precise molecular identities and functional contributions of these mediators remain elusive. In this study, we isolated exosomes from BAT and conducted miRNA sequencing, identifying miR-206-3p as a previously unrecognized exosomal miRNA with the potential to alleviate metabolic dysfunction-associated fatty liver disease (MAFLD). In vivo, adipose-specific knockout of miR-206-3p in mice exacerbated obesity-induced MAFLD, glucose intolerance, insulin resistance, and impaired energy expenditure. Mechanistically, BAT-derived miR-206-3p is selectively packaged into exosomes via a BAT-specific "exo motif" and transported to the l

SUBMITTER: Yang LJ 

PROVIDER: S-EPMC12507029 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature