Modeling of the Zn(II) Cysteine-Tyrosine dithiocarbamate Complex: Synthesis, Characterization, Molecular Docking and Anticancer Activity on MCF-7 Breast Cancer Cell Line.

ABSTRACT:

Objective

Cisplatin-based chemotherapy remains a widely used treatment for breast cancer, whether administered orally or intravenously. However, its clinical effectiveness is limited by poor selectivity, severe side effects, systemic toxicity, and the emergence of drug resistance. To overcome these limitations, this study investigates a novel molecular complex-Zn(II)-Cysteine-Tyrosine dithiocarbamate as a potential alternative with improved safety and efficacy in breast cancer therapy.

Methods

The complex was synthesized via a reaction involving zinc metal, cysteine, carbon disulfide (CS₂), potassium hydroxide (KOH), and tyrosine. It underwent comprehensive physicochemical characterization using Fourier-transform infrared (FT-IR) spectroscopy, UV-Vis spectroscopy, scanning e

SUBMITTER: Pratiwi E 

PROVIDER: S-EPMC12507066 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature