The Prognostic Role of Tumor-Stroma Ratio in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

The tumor-stroma ratio (TSR) has emerged as a potential prognostic marker in several cancers, including oral squamous cell carcinoma (OSCC). However, results with high certainty of evidence are required for its implementation in routine histological analysis. Therefore, this systematic review aims to summarize the evidence on the prognostic role of the TSR in OSCC.

Methods

A search was performed in Embase, PubMed, Scopus, Livivo, Web of Science, and Google Scholar. We included cohort studies that evaluated the association between TSR and survival. Reviews and studies that did not report hazard ratio (HR) were excluded.

Results

This systematic review included 10 studies and showed an association between TSR and survival. Low TSR (stroma-rich) was associated

SUBMITTER: De Oliveira DFG 

PROVIDER: S-EPMC12507072 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature