High-risk Sexual Behavior for HIV Acquisition is Associated with Gut Microbial Community in Men Who Have Sex with Men.

ABSTRACT:

Background

Gut dysbiosis is observed in men who have sex with men compared with men who have sex with women. However, the association between risk of HIV acquisition and gut microbiota in HIV sero-negative men who have sex with men remains unclear.

Methods

We conducted a cross-sectional study in HIV sero-negative men who have sex with men to explore the links between gut microbiota and risk of HIV acquisition. HIV sero-negative men who have sex with men were recruited. Fecal samples were collected for gut microbiota analysis using 16S rRNA gene sequencing. HIV risk assessment tool was used to estimate the risk of HIV acquisition. Latent class analysis was performed to categorize participants into different risk levels. Gut microbiota diversity was analyzed using the R packag

SUBMITTER: Li K 

PROVIDER: S-EPMC12507084 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature