Global Estimates of the HPV-related, Noncervical Cancer Burden in People With HIV and AIDS and the Potential Effect of Improved HPV Vaccine Coverage in This Population: A Systematic Review, Meta-analysis and Modeling Study.

ABSTRACT:

Background

While HIV/HPV coinfection significantly increases cervical carcinogenesis, the relationship with HPV-related noncervical cancers is less understood. HPV vaccination is key in prevention, but global coverage is low (21%). We aimed to quantify the risk of noncervical cancers among people living with HIV and AIDs (PWHA), estimate this cancer burden globally, and the impact of improved HPV vaccine coverage.

Methods

We conducted a systematic review and meta-analysis of 3 databases to identify studies comparing HPV-related noncervical cancer risk in PWHA and HIV negative populations, generating a risk ratio for each cancer. This was combined with country-specific HIV prevalence and the incidence of cancer cases to calculate the burden. Vaccine impact was estimated using

SUBMITTER: Wongkalasin N 

PROVIDER: S-EPMC12507086 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature