Uncovering α-synuclein and tau burden in Alzheimer's and Lewy body diseases.

ABSTRACT: Neurodegenerative diseases are classified based on their histopathological hallmarks alongside their clinical manifestations. Alzheimer's disease and Lewy body disease, which includes Parkinson's disease, are traditionally referred to as tauopathy and synucleinopathy, respectively. However, much like how Alzheimer's disease can present with Parkinsonian features and Parkinson's disease with cognitive impairment, there is considerable overlap in their underlying pathology. In this study, we applied antibodies specific for disease-related, post-translationally modified epitopes in α-synuclein and tau to post-mortem brain tissue from 16 Alzheimer's disease and 9 Lewy body disease cases with a focus on the substantia nigra and the locus coeruleus. We demonstrate the presence of inclusion patho

SUBMITTER: Quintin S 

PROVIDER: S-EPMC12507090 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature