Renal survival and improvement in younger malignant hypertension patients with thrombotic microangiopathy.

ABSTRACT: Hypertension (HTN) is increasing among young people. Notably, younger individuals are more susceptible to malignant hypertension (MHT). The occurrence and renal prognosis in MHT patients with thrombotic microangiopathy (TMA) across different age groups remains undetermined. This prospective cohort study evaluated 292 MHT patients with TMA in China from 2008 to 2023. We examined the clinical and pathological characteristics according to median age categories (≤35 years and >35 years). The associations of age with renal outcomes were examined in Cox regression models. The primary outcome was long-term renal replacement therapy (RRT). The secondary outcome was an increase of at least 15% in estimated glomerular filtration rate (eGFR). Among 292 patients, individuals younger than 35 years had

SUBMITTER: Li J 

PROVIDER: S-EPMC12507113 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature