Associations between blood-based neurodegenerative biomarkers and cognitive functioning and decline in India.

ABSTRACT: BackgroundMounting evidence supports the use of blood-based neurodegenerative biomarkers as a low-cost, minimally invasive tool for studying Alzheimer's disease and other dementias, but existing data largely come from clinical samples or high-income settings. Despite emphasis in the literature on the importance of understanding the utility of neurodegenerative biomarkers in diverse populations, published analyses are limited.ObjectiveTo assess the utility of neurodegenerative biomarkers in India by quantifying associations between biomarkers and cognitive outcomes in a nationally representative cohort study.MethodsWe quantified associations between five neurodegenerative blood biomarkers (amyloid-β 42/40 (Aβ_42/40), total tau, phosphorylated Tau181 (pTau-181), glial fibrillary ac

SUBMITTER: Nichols E 

PROVIDER: S-EPMC12507122 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature