Aortic Function in a Longitudinal 4D Flow MRI Study in Marfan Syndrome Patients Receiving Resveratrol.

ABSTRACT:

Background

New treatment strategies are required to reduce aortic events in Marfan syndrome (MFS). Resveratrol is a dietary supplement that intervenes in aortic wall cellular metabolism and may benefit MFS patients.

Purpose

To evaluate whether treatment with Resveratrol affects aorta hemodynamics derived from 4D flow MRI in MFS.

Study type

Prospective single-arm open-label multicenter trial.

Population

46 MFS patients (mean age 36 ± 9 years, 23 female), 20 with and 26 without a history of aortic root surgery (RR and native MFS), and 25 age- and sex-matched healthy controls.

Field strength/sequence

3T, temporally resolved 3D phase contrast (4D flow MRI) and 3D mDixon sequences.

Assessment

MFS patients underwent 4D flow MRI before (baseline) and aft

SUBMITTER: Bosshardt D 

PROVIDER: S-EPMC12507144 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature