Racial and Ethnic Disparities in Survival among Patients with Cholangiocarcinoma in the United States: A Systematic Review and Meta-analysis.

ABSTRACT:

Background

Cholangiocarcinoma (CCA) is an increasing cause of mortality in the United States; however, the burden of CCA disproportionately affects racial and ethnic minority groups. We aimed to characterize racial and ethnic differences in stage, treatment, and survival among patients with CCA.

Methods

We systematically searched MEDLINE and Embase through March 2023 for all studies reporting clinical outcomes among patients with CCA stratified by race and ethnicity. We calculated pooled HRs using the DerSimonian and Laird method for a random-effects model.

Results

Of 292 articles, 16 met inclusion criteria (n = 248,109 patients). Among six studies (n = 87,938) reporting overall survival, Black patients had worse survival [pooled HR, 1.05; 95% confidence interval (CI)

SUBMITTER: Shubin AD 

PROVIDER: S-EPMC12507172 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature